2, 3 In particular, when macrophages ingest atherogenic lipoprotein particles or clear apoptotic cells, their metabolic load is increased, promoting their metabolic rewiring. 1 Macrophages present within atherosclerotic plaques play a central role in the initiation, development, and complications of arterial plaques and rely on tightly integrated metabolic rewiring to maintain vessel wall integrity and continuously clear neighboring cells. The build-up of fat and cholesterol on the inner walls of arteries is strongly associated with their narrowing or blockage, a scenario that can be induced by a high-cholesterol diet in animals.
Atherosclerosis is the predominant cause of cardiovascular disease (CVD), which is the top cause of death in developed countries.
0 kommentar(er)
